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Date Published: 26/03/2025
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DOI: https://doi.org/10.51298/vmj.v547i1.12894
Issue
Vol. 547 No. 1 (2025)
Section
Các bài báo
How to Cite
Trịnh , T. H. C., Trần, N. D., Phan, T. P. P., Nguyễn, T. G. M., Nguyễn, T. P. V., & Trần, T. N. (2025). HLA-A AND HLA-B GENOTYPE FREQUENCY IN NASOPHARYNGEAL CARCINOMA PATIENTS. Vietnam Medical Journal, 547(1). https://doi.org/10.51298/vmj.v547i1.12894

HLA-A AND HLA-B GENOTYPE FREQUENCY IN NASOPHARYNGEAL CARCINOMA PATIENTS

Thị Hồng Của Trịnh , Ngọc Dung Trần, Thị Phi Phi Phan, Trịnh Gia Minh Nguyễn, Trần Phương Vy Nguyễn, Tín Nghĩa Trần

Main Article Content

Abstract

Background: The HLA (Human Leukocyte Antigen) gene is a genetic factor that plays an important role in the pathogenesis of nasopharyngeal carcinoma. Objective: Determine the frequency of HLA-A and HLA-B gene alleles in nasopharyngeal carcinoma patients at Can Tho Oncology Hospital. Materials and methods: A Cross-sectional descriptive study on 30 whole blood samples of patients with a confirmed diagnosis of nasopharyngeal carcinoma. Perform PCR-SSO (Polymerase Chain Reaction-Sequence Specific Oligonucleotide Probes) technique to survey the frequency of  HLA-A and HLA-B gene alleles, compare with the frequency of HLA-A and HLA-B alleles of the organ donor. Results: Among 30 nasopharyngeal cancer patients surveyed, the men (70%); The age ≥ 40 (80%); 7 types of HLA-A alleles and 16 types of HLA-B alleles, of which the most common alleles were -A*02 (40.4%), -A*11 (21.2%), -A*24 (21.2%) and -A*33 (9.6%); -B*15 (25%), -B*46 (23.1%), -B*38 (9.6%), -B*07 (7.7%). The difference betwween the frequency of HLA-A and HLA-B alleles in nasopharyngeal cancer patients with the control group was not statistically significant (p>0.05). Conclusion: Initial determination of the frequenncy of common HLA-A and HLA-B alleles in nasopharyngeal cancer patients were -A*02, -A*11, -A*24 and -B*15, -B*46, -B*38.

Article Details

Keywords

HLA, PCR-SSO, nasopharyngeal carcinoma.

References

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