BIẾN ĐỔI RỐI LOẠN CHỨC NĂNG CƠ QUAN VÀ MỐI LIÊN QUAN VỚI KẾT CỤC TRONG SỐC NHIỄM KHUẨN

Abstract

Objective: To investigate the association between the number of organ dysfunctions and SOFA scores at different time points with in-hospital mortality in patients with septic shock. Materials and methods: A prospective case series study was conducted on 82 patients with septic shock, defined by Sepsis-3 criteria, admitted to Hoan My Cuu Long Hospital from May 2023 to May 2024. Results: The number of organ dysfunctions and SOFA scores tended to decrease over time in the survivor group but showed no significant changes in the non-survivor group (p <0.05). The number of organ dysfunctions and SOFA scores at diagnosis were associated with in-hospital mortality, with the highest odds ratios of OR 2.66 (95% CI 1.38 – 5.15) and OR 1.47 (95% CI 1.18 – 1.84), respectively. The number of organ dysfunctions and SOFA scores at 24-hour predicted in-hospital mortality achieving the best area under the curve (AUC) of 0.78 (95% CI 0.68–0.88) for the number of organ dysfunctions with a cutoff point of 3.5, sensitivity of 0.90, and specificity of 0.66 (p <0.001); and at 0.84 (95% CI 0.75–0.93) for the SOFA score with a cutoff point of 8.5, sensitivity of 0.90, and specificity of 0.65 (p <0.001). Conclusion: The number of organ dysfunctions and SOFA scores showed a tendency to decrease over time in the survivor group but showed no significant changes in the non-survivor group. The number of organ dysfunctions and 24-hour SOFA scores had better predictive power for in-hospital mortality compared to other time points.