ĐÁNH GIÁ HIỆU QUẢ ĐIỀU TRỊ ĐAU ĐẦU NGÓN TAY BẰNG TIÊM BOTULINUM TOXIN TYPE A Ở NGƯỜI BỆNH XƠ CỨNG BÌ CÓ HIỆN TƯỢNG RAYNAUD TẠI BỆNH VIỆN ĐA KHOA TỈNH THANH HÓA

Abstract

Objective: To evaluate the effectiveness of treating Raynaud's phenomenon in patients with scleroderma with botulinum toxin type A (BTA) at Thanh Hoa General Hospital. Research method: cross-sectional, selecting patients treated with BTA, one hand was injected with BTA first and the other hand was injected after 1 month; the study compared the treatment effectiveness in the injected hand and the hand that had not been injected immediately before the second hand was injected. Results: 30 patients were treated with BTA. After 4 weeks from BTA injection in the non-dominant hand, the VAS pain score in the non-dominant hand decreased by an average of 0.60±0.86 (p<0.001), the VAS score in the dominant hand decreased by 0.17±0.79 (p=0.258); The average fingertip temperature of the BTA-injected hand group increased by 1.28±0.77oC (p<0.001), there was no change in the baseline temperature in the non-injected group (p=0.217); in the BTA-injected hand group, the temperature variation after cold stimulation increased from 2.43±0.58oC to 4.15±1.11oC (p<0.001), in the uninjected hand group there was no difference after 4 weeks (p=0.241). No serious side effects such as infection, bleeding, muscle weakness, or allergy were recorded. Conclusion: Local BTA injection can be effective and safe for the treatment of Raynaud's phenomenon in patients with scleroderma.