TÌNH HÌNH NHẠY CẢM KHÁNG SINH CỦA CÁC CHỦNG P.AERUGINOSA GÂY VIÊM PHỔI TẠI TRUNG TÂM HỒI SỨC TÍCH CỰC BỆNH VIỆN BẠCH MAI GIAI ĐOẠN 2024

Abstract

Objective: The study aims to investigate the antibiotic resistance of Pseudomonas aeruginosa strains causing pneumonia at the Intensive Care Unit – Bach Mai Hospital. Subjects and Methods: A prospective descriptive study was conducted on 91 adult patients treated at the Intensive Care Unit – Bach Mai Hospital, who were diagnosed with pneumonia according to CDC 2023 criteria and had positive microbiological results for Pseudomonas aeruginosa from lower respiratory tract specimens. Patients with a treatment duration of less than 72 hours, co-infection of Pseudomonas aeruginosa with other bacteria, and cases where Pseudomonas aeruginosa was a colonizing microorganism were excluded. Results: Among the isolated Pseudomonas aeruginosa strains, 77.4% were susceptible to ceftazidime/avibactam, while the resistance rate to meropenem was as high as 72.5%. The rate of Pseudomonas aeruginosa strains resistant to difficult-to-treat antibiotics was 58.1%. Among the strains resistant to meropenem, the susceptibility rate to ceftazidime/avibactam was 66.7%, and to ceftolozane /tazobactam was 10.6%. Conclusion: The study highlights the high rate of antibiotic resistance of Pseudomonas aeruginosa in the Intensive Care Unit, with a considerable resistance rate to carbapenem antibiotics, indicating the necessity for new treatment strategies for pneumonia caused by Pseudomonas aeruginosa in critically ill patients.