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STUDY OF LIPOPROTEIN (A) CONCENTRATIONS ≥125 NMOL/L IN PATIENTS WITH ATHEROSCLEROTIC CORONARY ARTERY DISEASE
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Abstract
A cross-sectional descriptive study of 450 subjects with a diagnosis of chronic coronary artery syndrome at Huu Nghi hospital. Lipoprotein (a) concentration was test at the department of Biochemintry, Bach Mai hospital. The study results showed that the proportion of subjects with Lp (a) concentration ≥ 125 nmol/l was 6,9%, of which the proportion with coronary artery stenosis ≥ 50% accounted for 87,1%. The risk of atherosclerotic coronary artery disease was 3,61 times higher when Lp (a) concentration ≥ 125 nmol/l (OR: 3,61; 95%CI: 1,239-10,515). Women with Lp (a) concentration ≥ 125 nmol/l had a 4,902 times higher risk of atherosclerotic coronary artery disease (OR: 4,902; 95%CI: 1,054 – 22,798).
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Keywords
Lipoprotein (a), chronic coronary artery syndrome
References
2. Baigent C, Koskinas KC, Casula M, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk: 78
3. Grundy SM, Stone NJ, Bailey AL, et al. 2018 aha/acc/aacvpr/aapa/abc/acpm/ada/ags/ apha/aspc/nla/pcna Guideline on the management of blood cholesterol: Executive summary. Circulation. 2019;139(25):e1082-e1143. doi:10.1161/CIR.0000000000000625
4. Jennifer L. Kelsey et al. Methods in Observational Epidemiology. 2nd edition. Oxford University Press; 1996
5. Reyes-Soffer G, Ginsberg HN, Berglund L, et al. Lipoprotein(a): A genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: A scientific statement from the American Heart Association. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022;42(1): e48-e60. doi:10.1161/ATV. 0000000000000147
6. Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. Statin therapy increases lipoprotein(a) levels. Eur Heart J. 2020;41(24): 2275-2284. doi:10.1093/eurheartj/ehz310
7. Tsimikas S, Fazio S, Ferdinand KC, et al. Unmet Needs in Understanding Lipoprotein(a) Pathophysiology: NHLBI Working Group Recommendations to Reduce Risk of Cardiovascular Disease and Aortic Stenosis. J Am Coll Cardiol. 2018;71(2):177-192. doi:10.1016/ j.jacc.2017.11.014
8. Salsoso R, Dalcoquio TF, Furtado RHM, et al. Relation of high lipoprotein (a) concentrations to platelet reactivity in individuals with and without coronary artery disease. Adv Ther. 2020;37(11): 4568-4584. doi:10.1007/s12325-020-01483-y