HOẠT ĐỘNG SỐNG HẰNG NGÀY VÀ CÁC YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN BỆNH PARKINSON MỚI CHẨN ĐOÁN

Abstract

Background: Initiation of pharmacological treatment in patients with newly diagnosed Parkinson's disease depends on the decline in function and/or quality of life. In particular, activities of daily living are considered one of the core parts of functional impairment assessment but have not been fully studied. Objectives: To determine the proportion of newly diagnosed Parkinson's disease patients whose activities of daily living are affected and related factors. Methods: This is a cross-sectional study conducting on patients with newly diagnosed Parkinson's disease according to the criteria of the 2015 International Parkinson and Movement Disorders Society at the Parkinson's and Movement Disorders Clinic, University Medical Center HCMC from November 2022 to June 2023. Demographic data, clinical characteristics, and MDS – UPDRS were collected from participating subjects. Data were analysed by using Rstudio-2023.06.01 and Epidata 4.6.0.6 software. Results: A total of 61 patients with Parkinson's disease met the criteria. The proportion of patients with newly diagnosed Parkinson's disease being effected on activities of daily living based on the MDS - UPDRS part II scale is 91.80%. Aspects in the classification of basic activities of daily living affected are respectively eating tasks (78.69%), dressing (73.77%), hygiene (63.93%), turning in bed (63.93%), getting out of bed (68.85%) and walking and balance (80.33%). The affected aspects in the classification of instrumental activities of daily living are handwriting (73.77%), doing hobbies and other activities (65.57%). When analysing multivariate regression, the factors affecting activities of daily living in patients with newly diagnosed Parkinson's disease are non-motor aspects of experiences of daily living based on MDS - UPDRS part I scores ( p = 0.005) and motor symptoms based on MDS – UPDRS part III score (p = 0.01). Conclusions: Impact on activities of daily living is very common in patients with newly diagnosed Parkinson's disease according to the MDS-UPDRS part II. Motor (MDS-UPDRS part III) and non-motor (MDS-UPDRS part I) symptoms independently correlate with patients' activities of daily living.