Article Sidebar

PDF
Date Published: 16/12/2021
Abstract Views: 771
Views PDF: 283
DOI: https://doi.org/10.51298/vmj.v507i1.1310
Issue
Vol. 507 No. 1 (2021)
Section
Các bài báo
How to Cite
Hùng Cường, N. ., & Đăng Tiến, N. . (2021). DETERMINATION OF SYNTHETIC CANNABINOID 5-FLUORO-MDMB-PICA IN NARCOTIC DRUGS BY GAS CHROMATOGRAPHY MASS SPECTROMETRY. Vietnam Medical Journal, 507(1). https://doi.org/10.51298/vmj.v507i1.1310

DETERMINATION OF SYNTHETIC CANNABINOID 5-FLUORO-MDMB-PICA IN NARCOTIC DRUGS BY GAS CHROMATOGRAPHY MASS SPECTROMETRY

Nguyễn Hùng Cường1,, Nguyễn Đăng Tiến2
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 National Institute of Criminal Sciences in HCMC

Main Article Content

Abstract

Objectives:A gas chromatography mass spectrometry (GC-MS) method was developed and validated for 5-FLUORO-MDMB-PICA innarcotic drugs. Subjects and methods: Synthetic cannabis samples contained in American grass collected in criminal cases in Vietnam from 2018 to 2020, were processed and used as test samples to validate the 5-FLUORO-MDMB-PICA GC-MS analyticalmethod according to ICH guidelines. Results: The 5-FLUORO-MDMB-PICA analytical, method was successfully developed withappropriate chromatographic conditions. The procedure was validatedwith suitablerepeatability and accuracywith a detection limit of 0,06 mg/mL. The average content of 5-FLUORO-MDMB-PICA in American grass was determined to be in the range of 2.2 mg per 100 mg of American grass(2,2%). Conclusions: For the first time in Vietnam, theanalytical method to determine 5-FLUORO-MDMB-PICA in American grass samples has been developed and validated. The process is simple, fast, inexpensive, and the results are highly reproduciblewith reliable, accuracy. The methodsatisfies all requirements according to ICH guidelines. Conclusively, this processcouldhelp to identify and quantify quickly and accuratelythe 5-FLUORO-MDMB-PICA incriminalevidences, andcan be widely applied in drug testing laboratories in Vietnam. This work, contributes to themethod development of assessing new synthetic cannabinoids, and develop national security standards in the fight against drug-related crimes.

Article Details

Keywords

Synthetic cannabinoids, 5-FLUORO-MDMB-PICA, GC-MS

References

1. Chính Phủ (2020), Nghị định số 60/2020/NĐ-CP ngày 29/05/2020 về sửa đổi, bổ sung danh mục các chất ma túy và tiền chất.
2. Truver Michael T, Watanabe Shimpei, ÅstrandAnna, Vikingsson Svante, Green Henrik, Swortwood Madeleine J, et al. (2020) "5F‐MDMB‐PICA metabolite identification and cannabinoid receptor activity". Drug Testing and Analysis, 12 (1), pp 127-135.
3. Krotulski Alex J, Mohr Amanda LA, Logan Barry K (2020) "Emerging synthetic cannabinoids: development and validation of a novel liquid chromatography quadrupole time-of-flight mass spectrometry assay for real-time detection". Journal of Analytical Toxicology, 44 (3), pp 207-217.
4. Mogler Lukas, Franz Florian, Rentsch Daniel, Angerer Verena, Weinfurtner Georg, Longworth Mitchell, et al. (2018) "Detection of the recently emerged synthetic cannabinoid 5F–MDMB‐PICA in ‘legal high’products and human urine samples". Drug testing and analysis, 10 (1), pp 196-205.
5. Risseeuw Martijn DP, Blanckaert Peter, Coopman Vera, Van Quekelberghe Stijn, Van Calenbergh Serge, Cordonnier Jan (2017) "Identification of a new tert-leucinate class synthetic cannabinoid in powder and “spice-like” herbal incenses: methyl 2-[[1-(5-fluoropentyl) indole-3-carbonyl] amino]-3, 3-dimethyl-butanoate (5F-MDMB-PICA)". Forensic science international, 273, pp 45-52.
6. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (2003), Stability Testing of New Drug Substances and Products, pp. 1-13.
7. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (2005), Validation of Analytical procedures: Text and methodology Q2(R1), pp. 1 – 13.
8. World Health Organization (2019) "Critical Review Report: 5F-MDMB-PICA".