NỒNG ĐỘ KHÁNG THỂ KHÁNG THYROID PEROXIDASE, KHÁNG THỂ KHÁNG THỤ THỂ THYROID-STIMULATING HORMONE TRONG HUYẾT THANH Ở BỆNH NHÂN RỤNG TÓC TỪNG VÙNG

Abstract

ntroduction: Alopecia areata is an autoimmune disease affecting hair follicles, leading to hair loss. Several studies have shown a link between alopecia areata and autoimmune diseases, particularly autoimmune thyroid disorders. Objective and Research Methods: This study aimed to determine the serum levels of TPO-Ab and TRAb and their relationship with clinical characteristics in patients with alopecia areata visiting the Ho Chi Minh City Dermatology Hospital. A case series descriptive study with a control group was designed, including 33 patients with alopecia areata and 25 healthy individuals matched for age and gender. Results: The levels of TPO-Ab and TRAb in the alopecia areata (AA) patient group were significantly higher than those in the healthy control group (p = 0.008 and 0.0003, respectively). Serum TPO-Ab and TRAb levels in patients with limited AA (S1, S2 according to SALT) were significantly lower than those in patients with extensive AA (S3, S4 according to SALT) (p = 0.045 and 0.036, respectively). Serum TRAb levels were significantly higher in patients with comorbid atopic conditions compared to those without comorbid atopic conditions (p = 0.005). Additionally, serum TPO-Ab levels in patients with comorbid atopic and/or autoimmune diseases were significantly different from those without comorbid atopic and/or autoimmune diseases (p = 0.017 and 0.019, respectively). Conclusion: Serum TPO-Ab and TRAb levels in the alopecia areata (AA) group were higher than those in healthy individuals, and the elevation was associated with disease severity and certain characteristics, such as comorbid atopic dermatitis and/or autoimmune diseases. Measuring serum TPO-Ab and TRAb levels in AA patients, especially those with severe disease and comorbidities including atopic dermatitis and/or autoimmune disease, is crucial.