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Date Published: 02/04/2025
Abstract Views: 78
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DOI: https://doi.org/10.51298/vmj.v547i3.13246
Issue
Vol. 547 No. 3 (2025)
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Các bài báo
How to Cite
Đặng Thái, T., Phạm Việt, N., Nguyễn Thị, X., Đặng Thành, C., & Trần Ngọc, D. (2025). TLR4, MYD88 GENES POLYMORPHISMS AND THEIR RELATIONSHIP WITH PATHOLOGICAL FEATURES IN COLORECTAL ADENOCARCINOMA. Vietnam Medical Journal, 547(3). https://doi.org/10.51298/vmj.v547i3.13246

TLR4, MYD88 GENES POLYMORPHISMS AND THEIR RELATIONSHIP WITH PATHOLOGICAL FEATURES IN COLORECTAL ADENOCARCINOMA

Trà Đặng Thái, Nhật Phạm Việt, Xuân Nguyễn Thị, Chung Đặng Thành, Dũng Trần Ngọc

Main Article Content

Abstract

Objective: To determine single nucleotide polymorphisms of TLR4 and MyD88 genes and their relationship with prognostic pathological features in colorectal adenocarcinoma. Subjects and methods:  A cross-sectional study of 176 patients with colorectal adenocarcinoma and 131 patients with colorectal adenoma at Military Hospital 103 from April 2021 to June 2024. Pathological features were evaluated and gene polymorphisms were determined by Sanger sequencing on DNA from FFPE samples. Results: The predominant histological type was conventional adenocarcinoma (84.66%), moderately differentiated (74.43%), pT3-T4 stages (75.6%). Two significant SNPs were identified: TLR4 9:117713042 (A>G) and MyD88/rs138284536, with heterozygous genotypes significantly associated with mucinous type, advanced tumor stage, and perineural invasion. Conclusion: TLR4 9:117713042 (A>G) and MyD88/rs138284536 are associated with poor prognostic pathological features in colorectal adenocarcinoma.

Article Details

Keywords

Colorectal adenocarcinoma, Single nucleotide polymorphism, TLR4 gene, MyD88 gene, Pathological features, Prognostic factors

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