EVALUATION OF ANTIBIOTIC TREATMENT OUTCOMES IN UNCOMPLICATED ACUTE APPENDICITIS

Văn Đợi Mai, Văn Năng Phạm

Main Article Content

Abstract

Background: Acute appendicitis is common in abdominal emergencies, with a risk of about 7-8%. Appendectomy is the main treatment, with a mortality rate of 0.7-2.4% with and without complications. The success rate of treating uncomplicated appendicitis with antibiotics is high (75-85%) in 1 year of follow-up has been proven. Objective: To evaluate the results of conservative treatment of uncomplicated acute appendicitis with antibiotics. Subjects and methods: Prospective, descriptive study of 136 patients with acute appendicitis at Can Tho University of Medicine and Pharmacy Hospital from August 2022 to February 2025. Results: Male/female = 6:7, mean age: 38.5±13.7 years old. The average time of disease onset, hospitalization and sick leave were 24.8±20.3 hours, 2.85±0.84 days and 4±0.5 days, respectively. During 24 hours of follow-up, 2 cases underwent emergency surgery (1.47%). Normal colonoscopy accounted for 88.2% and 11.8% of colon polyps (tubular polyps). During 1 year of follow-up, the recurrence, failure and mortality rates were 17.6%; 19.12% and 0%, respectively. Conclusion: Treatment of uncomplicated acute appendicitis with antibiotics is safe and feasible. Close monitoring is needed in the first 24 hours of treatment to detect and perform emergency surgery in cases of failure.

Article Details

References

1. Coursey C A, Nelson R C, Patel M B, et al (2010), "Making the diagnosis of acute appendicitis: do more preoperative CT scans mean fewer negative appendectomies? A 10-year study", Radiology, 254(2), pp. 460-468.
2. Sippola S, Grönroos J, Tuominen R, et al (2017), "Economic evaluation of antibiotic therapy versus appendicectomy for the treatment of uncomplicated acute appendicitis from the APPAC randomized clinical trial", Br J Surg, 104(10), pp. 1355-1361.
3. Flum D R, Davidson G H, Monsell S E, et al (2020), "A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis", N Engl J Med, 383(20), pp. 1907-1919.
4. Alnaser M K H, Hassan Q A, Hindosh L N (2018), "Effectiveness of conservative management of uncomplicated acute appendicitis: A single hospital based prospective study", International Journal of Surgery Open, 10(pp. 1-4).
5. Park H C, Kim M J, Lee B H (2017), "Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis", Br J Surg, 104(13), pp. 1785-1790.
6. Vương Thừa Đức, Nguyễn Tạ Quyết (2008), "Cắt ruột thừa nội soi ở người nhiều tuổi", Tạp chí Y Học Việt Nam, (1), pp. 207-214.
7. Phạm Văn Năng, Phạm Văn Lình (2014), "Viêm ruột thừa", Bệnh học Ngoại khoa Tiêu hóa- Gan mật, pp. 102-111.
8. Phan Minh Trí, Đỗ Đình Công (2021), "Viêm ruột thừa cấp", Bệnh học Ngoại khoa Tiêu hóa, pp.8-32.
9. Javanmard-Emamghissi H, Boyd-Carson H, Hollyman M, et al (2021), "Correction to: The management of adult appendicitis during the COVID‑19 pandemic: an interim analysis of a UK cohort study", Tech Coloproctol, 25(1), pp. 149.
10. Salminen P, Tuominen R, Paajanen H, et al (2018), "Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial", Jama, 320(12), pp. 1259-1265.