ĐẶC ĐIỂM RỐI LOẠN ĐÔNG MÁU Ở TRẺ MẮC COVID-19 CÓ SỬ DỤNG KHÁNG ĐÔNG TẠI BỆNH VIỆN NHI ĐỒNG 1 NĂM 2021-2022

Abstract

Objectives: To determine the clinical and paraclinical characteristics and hemostatic disorders in children with COVID-19. Subjects and Methods: This retrospective case series study included 181 children with COVID-19 who were treated with anticoagulants in the Infectious Diseases Intensive Care Unit of Children’s Hospital 1 from July 1, 2021, to April 30, 2022. Results: The median age was 20 months, with 51.4% of cases being under 12 months of age. Male predominance was observed, with a male-to-female ratio of 1.6:1. Underlying conditions were present in 42.9% of cases. The most common clinical symptoms were fever (79.6%), cough (80.1%), and dyspnea (59.1%). Among the cases, 83 (45.9%) had moderate COVID-19, 94 (51.9%) had severe disease, and 4 (2.2%) were critical. Chest X-ray findings revealed pulmonary consolidation (49.7%) and interstitial changes (31.3%) as the most common abnormalities. Coagulation disorders were identified in 90.1% of cases, including hypercoagulability in 70.7%, hypocoagulability in 1.1%, and mixed tendency in 19.3%. The proportion of females and ferritin levels were higher in the group with coagulation disorders compared to the normal group, with a statistically significant difference. Conclusion: Coagulation disorders, particularly hypercoagulability, are common among children with COVID-19. Further studies on coagulation disorders and the use of anticoagulants in pediatric COVID-19 patients are warranted.