SO SÁNH PHÁC ĐỒ PPOS VÀ ANTAGONIST: ĐÁNH GIÁ BAN ĐẦU VỀ KẾT QUẢ ĐIỀU TRỊ VÀ QUÁ TRÌNH PHÁT TRIỂN PHÔI QUA HỆ THỐNG TIME-LAPSE TẠI BỆNH VIỆN PHỤ SẢN HÀ NỘI

Abstract

Objectives: This study compares the outcomes and embryo development dynamics between two ovarian stimulation protocols—Progestin-Primed Ovarian Stimulation (PPOS) and GnRH Antagonist—using a time-lapse monitoring system for in vitro fertilization (IVF) cycles. Subjects and methods: A total of 192 patients were divided evenly between the PPOS group (96 patients) and the GnRH antagonist group (96 patients), treated from July to December 2022 at the Hanoi Obstetrics and Gynecology Hospital. Key parameters compared include ovarian stimulation duration, fertilization rates, the number and quality of D5 embryos, and embryo kinetics observed through the time-lapse system.  Results: The study found that ovarian stimulation in the PPOS group was significantly shorter than in the GnRH antagonist group (P<0.05), and the serum LH level on the trigger day was lower in the GnRH antagonist group (P<0.05). However, there were no significant differences in pregnancy rates or clinical pregnancy rates between the two groups. Conclusion: The conclusion suggests that dydrogesterone can replace GnRH antagonists to prevent premature LH surges, offering advantages such as oral administration and potential cost savings.