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Date Published: 16/12/2021
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DOI: https://doi.org/10.51298/vmj.v507i1.1336
Issue
Vol. 507 No. 1 (2021)
Section
Các bài báo
How to Cite
Ngọc Nhất, N. ., Thế Sơn, T. ., Thanh Tùng, N. ., Ngọc Thảo My, T. ., Đức Minh, P. ., & Tiến Sang, T. . (2021). EVALUATING THE ASSOCIATION BETWEEN GENETIC POLYMORPHISMS RELATED TO HOMOCYSTEINE METABOLISM AND RECURRENT PREGNANCY LOSS. Vietnam Medical Journal, 507(1). https://doi.org/10.51298/vmj.v507i1.1336

EVALUATING THE ASSOCIATION BETWEEN GENETIC POLYMORPHISMS RELATED TO HOMOCYSTEINE METABOLISM AND RECURRENT PREGNANCY LOSS

Nguyễn Ngọc Nhất1,, Trịnh Thế Sơn1, Nguyễn Thanh Tùng1, Trần Ngọc Thảo My2, Phạm Đức Minh1, Triệu Tiến Sang1
1 Vietnam Military Medical University
2 Faculty of Science and Engineering, Sorbonne University

Main Article Content

Abstract

Objectives: This study aimed to investigate the association between of MTHFR C677T, MTHFR A1298C, MTR A2756G, and MTRR A66G polymorphisms related to homocysteine metabolism among Vietnamese women with unexplained recurrent pregnancy loss. Materials and method: a case–control study including 92 women with unexplained recurrent pregnancy loss and 92 healthy controls in multiple centers. Results: The mean age were 29,58 ± 2,91 and 30,69 ± 2,44 for case and control groups, separately. MTHFR C677T and MTR A2756G mutant alleles were found to be significantly more prevalent in patients than controls (p > 0,05), which led to an increase in the risk of recurrent pregnancy loss as 2.33 and 1.82 fold (OR 2.33; 95% CI, 1.38-3.96 and OR 1.82; 95% CI, 1.02-3.29), respectively. Otherwise, A > C nucleotide alternation for the MTHFR mutation as well as A > G for the MTRR mutation did not show significant risk in our study (P>0.05). Conclusion: MTHFR C677T and MTR A2756G polymorphisms are risk factors of recurrent pregnancy loss in Vietnamese women, these results are similar to that in other studies around the world. According to the association, we recommend genetic testing for women with unexplained recurrent pregnancy loss.

Article Details

Keywords

recurrent pregnancy loss, homocysteine, MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G

References

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