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THE EARLY OUTCOMES OF GAMMA KNIFE RADIOSURGERY COMBINED WITH TKIS IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER WITH BRAIN METASTASES
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Abstract
Objectives: Evaluate the early outcomes of non-small cell lung cancer (NSCLC) patients with brain metastases treating by Gamma Knife radiosurgery combined with TKIs. Methods: Cross-sectional descriptive study, 65 patients who received Gamma Knife radiosurgery combined with EGFR TKIs from January 2022 to December 2024. Results: At 6 months, the intracranial disease control rate was 95,4%, complete response was 38,5%, and the extracranial disease control rate was 89,2%. The pretreatment total tumor volume and localized neurological symptoms relate to intracranial response. Conclusion: Gamma Knife radiosurgery combined with TKIs is effective in controlling brain metastases and improving clinical symptoms in NSCLC patients with brain metastases.
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Keywords
non small cell lung cancer, brain metastases, Gamma Knife, TKIs.
References
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