ĐẶC ĐIỂM BỆNH NHI NHIỄM HO GÀ ĐIỀU TRỊ TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Objective: Describe the characteristics of children with pertussis treated at the National Children's Hospital. Subjects and methods: Children under 16 years old were diagnosed with pertussis by real-time PCR, and treated at the National Children's Hospital from January 2019 to December 2020. Results: The majority of children with whooping cough hospitalized were children under 4 months old (75.7%), the rate of boys with pertussis was higher than that of girls (male/female ratio ≈ 1.23/1). Most children with whooping cough were unvaccinated, accounting for 85.9% (328/382). The number of whooping cough cases is scattered throughout the year, however, the disease tends to be lower in the winter months. The most common day for Real-time PCR testing for whooping cough was the 10th day, with an average of 12.4 days. 23.6% (90/382) of children with whooping cough had co-infections with microbial pathogens, mainly viral co-infection 70.0% (63/90), bacterial co-infection 40.0% (36/90) and fungal co-infection 1.1% (1/90). Notably, 17.8% (16/90) of children had superinfections with at least 2 microbial pathogens. Conclusion: The majority of children with whooping cough hospitalized were children under 4 months old, and had not reached the age of vaccination. The rate of children with whooping cough is predominant viral co-infection. Real-time PCR technique is meaningful in the early diagnosis of whooping cough in children.