MỨC ĐỘ NHẠY CẢM KHÁNG SINH CỦA CÁC CHỦNG MORAXELLA CATARRHALIS PHÂN LẬP ĐƯỢC TẠI BỆNH VIỆN ĐA KHOA TÂM ANH NĂM 2023

Abstract

Moraxella catarrhalis is an aerobic, gram-negative bacterium associated with respiratory tract infections. Its increasing resistance to commonly used antibiotics poses significant challenges to treatment. Methods: This cross-sectional study aimed to assess the distribution characteristics and antimicrobial susceptibility patterns of M. catarrhalis strains isolated at Tam Anh General Hospital in 2023. Results: Of 465 M. catarrhalis isolates, the highest distribution rate of M. catarrhalis was observed in children aged 1-4 years (82.8%), with a declining trend in older age groups. Most isolates were from male patients (58.9%), predominantly in the Pediatrics Department (99.4%). The strains exhibited the lowest susceptibility to azithromycin (36.3%) and cefuroxime (52.5%), while demonstrating the highest sensitivity to levofloxacin (99.7%). No resistance was detected to meropenem or amoxicillin-clavulanate among the isolates. Conclusions: M. catarrhalis primarily affects young children, with its prevalence decreasing from 5 years of age. The study highlights the importance of reasonable antibiotic use to mitigate the rise of antibiotic resistance. Meropenem, amoxicillin-clavulanate, and levofloxacin remain the most effective treatment options for M. catarrhalis infections.