BƯỚC ĐẦU KHẢO SÁT BIỂU HIỆN HOÁ MÔ MIỄN DỊCH CỦA SLAIN2 TRÊN BỆNH NHÂN UNG THƯ BIỂU MÔ TẾ BÀO GAI NIÊM MẠC MIỆNG

Abstract

Introduction: SLAIN2 (SLAIN motif-containing protein 2) is a protein that plays a crucial role in regulating cell morphology and movement, with varying levels of expression depending on the type of cancer. However, no studies have investigated the expression of SLAIN2 in patients with oral squamous cell carcinoma (OSCC). Objective: To survey the expression and analyze the relationship between SLAIN2 expression levels and clinical-pathological characteristics in OSCC. Method: A retrospective study was conducted on 52 paraffin-embedded tissue samples from OSCC patients who were examined and treated at Ho Chi Minh City Oncology Hospital. Tissue samples were cut into 3-4µm sections and stained with Hematoxylin-Eosin (HE) and immunohistochemistry using a polyclonal SLAIN2 antibody to determine SLAIN2 expression levels via the H-score. Results: The rate of SLAIN2 expression in the study was 30% strong expression and 70% weak expression. Smoking and alcohol consumption significantly impacted SLAIN2 expression levels, with smokers and drinkers showing strong expression compared to non-smokers and non-drinkers (p<0.05). The clinical lymph node metastasis rate was 69.2% in the strong SLAIN2 expression group, compared to 53.8% in the weak expression group (p=0.037). Conclusion: SLAIN2 expression may influence lymph node metastasis in OSCC patients by affecting the invasive mechanisms of cancer cells, thereby impacting prognosis and disease progression.