TÌM HIỂU BIẾN THIÊN NHỊP TIM Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TYP 2 CÓ ĐƯỜNG HUYẾT KHÔNG ỔN ĐỊNH

Abstract

Heart rate variability (HRV) reflects cardiac autonomic nervous function and predicts risk of serious arrhythmia and mortality. Diabetes mellitus patients have high rate cardiac autonomic nervous dysfunction and arterial diseases, so they are reduced quality of life and significantly increased cardiovascular mortality. The aim of this study was to examine Heart rate variability in diabetes mellitus participants with uncontrol blood glucose level and the relationship between heart rate variability and blood glucose level from 24-h Holter electrocardiogram recordings. Method: We performed a cross – sectional study included 50 diabetes mellitus participants with unstable blood glucose level from 24-h Holter–electrocardiogram recordings and was followed by a finger prick blood glucose assessment glucose 5 times (6h-11h-13h-17h-21h). Results: SDNN(Standard deviation of all normal sinus R-R intervals), ASDNN (The mean of the standard deviation of all normal sinus R-R intervals for all 5-minute segments of the entire recording), SDANN (Standard deviation of the averaged normal sinus R-R intervals for all 5 minute segments of the entire recording), RMSSD (The root mean square of the difference between the coupling intervals of adjacent R-R intervals) are lower in diabetes mellitus participants than normal. HRV in hypoglycemia group is lower no significant than hyperglycemia group’s. Correlation analysis identified that there was no significant relationship between any HRV time domain parameter and blood glucose level in the diabetes mellitus participants. SDNN, ASDNN, SDANN in hyperglycemia group was significantly correlations with HbA1c but no significantly negatively correlated in hypoglycemia group. QTc max was longer in hypoglycemia group and was negatively correlated with blood glucose levels at 6 a.m, 11 a.m (fasting plasma glucose). There was no correlations between arrhythmia and blood glucose levels. Conclusions: HRV time domain parameters in Diabetes mellitus typ 2 patients are lower than normal and moderate correlations with HbA1c, weak correlations with blood glucose levels.