ĐÁNH GIÁ HIỆU QUẢ CỦA PHƯƠNG PHÁP AN THẦN DO BỆNH NHÂN TỰ ĐIỀU KHIỂN BẰNG PROPOFOL ĐỂ CHỌC HÚT NOÃN THỤ TINH TRONG ỐNG NGHIỆM

Abstract

Objectives: Evaluation of the effectiveness of patient-controlled sedation with propofol (PCS) for in vitro fertilization. Methods: Prospective, randomized, comparative clinical trial, 60 patients with oocyte retrieval were randomly assigned to 2 groups. Group 1 (PCS group, n1 = 30) used patient-controlled sedation (Propfol 1% drug, each time the patient presses the machine will inject 20mg, no refractory time set Group 2 (GM group), n2 = 30) was the usual intravenous anesthesia group (Propofol 1% dose 2mg/kg intravenous intermittent controlled by the anesthesiologist). Patients in both groups received 0.05 mg 50 mcg fentanyl. intravenous injection and paracervical anesthesia with 100mg lidocaine 1%.We assessed the degree of sedation (OAA/S), total dose of propofol, time to recovery and discharge, and the patient's movement rate during procedure, patient and surgeon satisfaction. Results: The PCS group had an average sedation level of 3.87 to 4.2 points while the GM group had a sedation level of 1.6 to 2.1 points (due to the amount of propofol consumed in the PCS group was 52.7±11 points). 1 mg lower than GM group (151.7±18.9 mg), recovery time and hospital discharge time of PCS group (1.7±0.5 and 56.6±15.4) as well. lower than that of the GM group (6.9±1.9 and 86.5±25.4) with p < 0.05. The percentage of patients moving during the procedure, the surgeon's satisfaction level and of patients of the 2 groups there was no difference. Conclusion: Patient-controlled sedation (PCS) with Propofol, combined with paracervical anesthesia with lidocaine in oocyte retrieval has good analgesia, helps patients reduce deep sedation, reduce anesthetic consumption, reduced recovery time and hospital discharge time compared with the conventional intravenous anaesthesia group.