ĐẶC ĐIỂM LÂM SÀNG RỐI LOẠN CHỨC NĂNG TUYẾN MEIBOMIAN TRÊN BỆNH NHÂN KHÔ MẮT CÓ HỘI CHỨNG SJÖGREN NGUYÊN PHÁT

Abstract

Objectives: Describe the clinical characteristics of meibomian gland dysfunction (MGD) in dry eye patients with primary Sjögren’s syndrome (pSS) and review the association between meibomian gland dysfunction and dry eye disease in patients with primary Sjögren’s syndrome. Subjects and methods: Case study research is conducted in 20 dry eye patients (40 eyes) with pSS at the Cornea Department of Vietnam National Eye Hospital. Results: The average age of the patients is 53,2 ± 11,7, female – to – male ratio is of 9/1. Function of meibomian glands is disordered at many levels: change in lid morphology (thick lid margin: 55%, lid margin hyperemia: 50%, meibomian orifice plug: 42,5%); expressibility of meibomian glands is principally grade 1 (50%) and grade 2 (37,5%); quality of expressed lipid is mostly cloudy fluid (57,5%); meibomian gland dropout from grade 1 or higher accounts for 90%. Dry eye severity level has association with expressibility of meibomian gland. There is no relationship between dry eye severity level and quality of expressed lipid, meibomian gland dropout level. There is no relationship between MGD severity level and dry eye severity levels. Conclusions: pSS patients express various levels of MGD. There is no clear association between MGD and dry eye in pSS patients.