THỰC TRẠNG KHÁNG KHÁNG SINH CỦA CÁC CHỦNG STREPTOCOCCUS PNEUMONIAE PHÂN LẬP ĐƯỢC TẠI BỆNH VIỆN ĐA KHOA TÂM ANH NĂM 2023

Abstract

Streptococcus pneumoniae is a major pathogen responsible for respiratory and other infections in both children and adults. Increasing antibiotic resistance in this bacterium poses significant challenges to effective treatment. Methods: This cross-sectional study assessed the distribution and antibiotic resistance profiles of S. pneumoniae strains isolated at Tam Anh General Hospital in 2023. Results: Of 305 S. pneumoniae isolates, the highest rate of S. pneumoniae was observed in the 0–5 age group (93.1%), with a decreasing trend in older age groups. The bacterium was more frequently isolated in males (54.8%) than females (45.2%) and was predominantly found in pediatric patients (97.7%) and respiratory specimens (99.0%). High resistance rates were noted for erythromycin (98.4%), clindamycin (95.7%), tetracycline (90.5%), and trimethoprim-sulfamethoxazole (57.0%), while resistance to other antibiotics remained below 9%. No resistance was observed to vancomycin, rifampin, or linezolid. Conclusion: S. pneumoniae primarily causes respiratory infections in young children, with a decreasing distribution rate in older age groups. The high rates of resistance to commonly used antibiotics underscore the urgent need for stringent antibiotic stewardship to mitigate the spread of resistance and preserve treatment efficacy.