NGHIÊN CỨU SỰ BIẾN ĐỔI NỒNG ĐỘ SEROTONIN, CORTISOL HUYẾT THANH Ở BỆNH NHÂN RỐI LOẠN HỖN HỢP LO ÂU VÀ TRẦM CẢM DƯỚI ẢNH HƯỞNG CỦA ĐIỆN CHÂM

Abstract

Objective: Study the changes in serum Serotonin and Cortisol levels in patients with mixed anxiety and depression disorders treated with electroacupuncture in Hanoi. Subjects and methods: 120 patients diagnosed with mixed anxiety and depression disorders (F41.2) according to ICD-10 criteria were divided into two groups: The intervention group was treated with electroacupuncture combined with medication according to the treatment regimen for mixed anxiety and depression disorders of Hanoi Psychiatric Hospital, the control group was treated with medication according to the treatment regimen for mixed anxiety and depression disorders of Hanoi Psychiatric Hospital in a 56-days treatment course. Serum Serotonin and Cortisol levels were evaluated at 2 time points after 28 days and 56 days of treatment using ELISA technique. Results: After the treatment, the serum Serotonin and Cortisol levels in both study groups improved significantly compared to before treatment (p < 0.01). The improvement in serum Serotonin levels in the intervention group was statistically significantly better than that in the control group, with p < 0.05. The intervention group tended to improve serum Cortisol levels better than the control group, however, the difference was not statistically significant, p > 0.05. Conclusion: Electroacupuncture has the effect of changing the serum Cortisol and Serotonin levels, two basic substances in the pathogenesis of mixed anxiety and depression disorders, thereby confirming the supportive treatment effect of electroacupuncture on some types of mixed anxiety and depression disorders.