Article Sidebar

PDF
Date Published: 16/12/2021
Abstract Views: 135
Views PDF: 122
DOI: https://doi.org/10.51298/vmj.v507i1.1346
Issue
Vol. 507 No. 1 (2021)
Section
Các bài báo
How to Cite
Văn Tuấn, M. ., Văn Xuân, V. ., Chính Đại, L. ., Trung Bách, T. ., & Thị Hồng Thắm, N. . (2021). EVALUATION OF INITIAL RESULTS OF PET/CT APPLICATION TO PLAN RADIATION THERAPY FOR ESOPHAGEAL CANCER. Vietnam Medical Journal, 507(1). https://doi.org/10.51298/vmj.v507i1.1346

EVALUATION OF INITIAL RESULTS OF PET/CT APPLICATION TO PLAN RADIATION THERAPY FOR ESOPHAGEAL CANCER

Mai Văn Tuấn1,, Võ Văn Xuân2, Lê Chính Đại1, Trần Trung Bách1,2, Nguyễn Thị Hồng Thắm2
1 Hanoi Medical University
2 K Hospital

Main Article Content

Abstract

Background: Defining the target volume of the primary tumor in esophageal cancer and in metastatic lymph nodes are usually based on computed tomography (CT) can be difficult given the low soft-tissue contrast of CT resulting in large interobserver variability. We evaluated the value of a dedicated planning 18FDG -Positron emission tomography/ computer tomography (PET/CT) for harmonization of gross tumor volume (GTV) delineation and the feasibility for planning purposes in a large cohort. Methods: Thirty patients diagnosed with EC had undergon prior PET/CT simulation and CT simulation. The GTV­CT was contoured on the CT image without the PET/CT image. GTVPET was contoured on the PET/CT image. Differences in the lymph node metastasis (LNM); volume, length among the target volumes were determined. Results: significantly more LNM were identified with 18FDG PET/CT compared CT alone (88 LNM vs 62 LMM, p: 0.000). 13/30 patients with nodal stage change after using PET/CT image. 18FDG PET/CT was decreased absolute length of tumor by 1.8cm (23%) in 18 patients. Significantly smaller GTV based on PET/CT imaging. Conclusion: significantly more LNM were identified with 18FDG PET/CT compared CT alone. 18FDG PET/CT was decreased length of tumor and gross tumor volume compare with CT alone. Therefore, PET/CT can be used to optimize the definition of the target volume in EC.

Article Details

Keywords

PET/CT, radiation therapy, esophageal cancer

References

1. van Hagen P., Hulshof M.C.C.M., van Lanschot J.J.B. và cộng sự. (2012). Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med, 366(22), 2074–2084.
2. Münch S., Marr L., Feuerecker B. và cộng sự. (2020). Impact of 18F-FDG-PET/CT on the identification of regional lymph node metastases and delineation of the primary tumor in esophageal squamous cell carcinoma patients. Strahlenther Onkol, 196(9), 787–794.
3. Shi J., Li J., Li F. và cộng sự. (2021). Comparison of the Gross Target Volumes Based on Diagnostic PET/CT for Primary Esophageal Cancer. Front Oncol, 11, 550100.
4. Garcia B., Goodman K.A., Cambridge L. và cộng sự. (2016). Distribution of FDG-avid nodes in esophageal cancer: implications for radiotherapy target delineation. Radiation Oncology, 11(1), 156.
5. Konski A., Doss M., Milestone B. và cộng sự. (2005). The integration of 18-fluoro-deoxy-glucose positron emission tomography and endoscopic ultrasound in the treatment-planning process for esophageal carcinoma. Int J Radiat Oncol Biol Phys, 61(4), 1123–1128.
6. Toya R., Matsuyama T., Saito T. và cộng sự. (2019). Impact of hybrid FDG-PET/CT on gross tumor volume definition of cervical esophageal cancer: reducing interobserver variation. Journal of Radiation Research, 60(3), 348–352.
7. Vesprini D, Ung Y, Dinniwell R et al (2008) Improving observer variability in target delineation for gastro-oesophageal cancer—the role of 18F-fluoro-2-deoxy-D-glucosepositron emission tomogra- phy/computed tomography. Clin Oncol 20:631–638.