TÁC NHÂN VI SINH GÂY VIÊM PHỔI CỘNG ĐỒNG KÉM ĐÁP ỨNG ĐIỀU TRỊ Ở TRẺ EM TẠI BỆNH VIỆN ĐA KHOA ĐỒNG THÁPTÁC NHÂN VI SINH GÂY VIÊM PHỔI CỘNG ĐỒNG KÉM ĐÁP ỨNG ĐIỀU TRỊ Ở TRẺ EM TẠI BỆNH VIỆN ĐA KHOA ĐỒNG THÁP

Abstract

Background: Poor response to treatment of community-acquired pneumonia (CAP) in children is an issue that needs attention. Objective: To determine the percentage of microbial agents causing CAP with poor response in children at Dong Thap General Hospital; to investigate the relationship between groups of microbial agents and clinical and paraclinical characteristics. Materials and methods: Cross-sectional descriptive study of 93 children with CAP at Dong Thap General Hospital from June 2024 to Feb 2025. All of children had been conducted nasotracheal aspiration and performed real-time PCR (polymerase chain reaction) to find 70 microbial agents. Results: Most children were under 24 months old (74.1%), the male: female ratio was approximately 2:1. The rate of detection of microbial agents via real-time PCR was 81/93 (87.1%); In which, the majority had the presence of bacteria (66.7%). Streptococcus pneumoniae and Haemophilus influenzae were the two leading bacterial pathogens with rates of 46.2% and 20.9%, respectively. Children with CAP mainly had clinical symptoms such as crackles (100%), cough (93.8%), and rapid breathing (82.7%). There was no difference in clinical and paraclinical symptoms between the bacterial and viral infection groups (p>0.05), except for high neutrophils in the bacterial infection group (p=0.007). Conclusion: The presence of bacteria is an important factor to consider in the causes of CAP in children. However, except for high neutrophils in the bacterial infection group, there were no clinical and paraclinical symptoms that helped differentiate bacterial and viral agents causing CAP in children.