VAI TRÒ CỦA CEA TRONG ĐÁNH GIÁ ĐÁP ỨNG HÓA TRỊ UNG THƯ ĐẠI TRỰC TRÀNG GIAI ĐOẠN TÁI PHÁT, DI CĂN

Abstract

Aims: To evaluate the efficacy of carcinoembryonic antigen (CEA) for monitoring tumour response during chemotherapy in recurrent, metastatic colorectal cancer (CRC). Patients and method: Retrospective description study of 81 recurrent, metastatic colorectal cancer patients that had initial CEA level more than 5ng/ml and treated with Oxaliplatin-based or Irinotecan-based chemotherapy. Serum CEA levels were measured and computed tomography (CT) workups were performed before chemotherapy treatments and after every 3 cycles of chemotherapy. Results: The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of CEA assessment for prediction of disease response (complete or partial) and progression were 82,0%, 63,1%, 63,1%, 82,0%, 71,3% and 61,1%, 80,4%, 36,7%, 91,8% respectively. Conclusions: SerumCEA levels could be useful for monitoring tumour response and progression during chemotherapy in recurrent, metastatic colorectal cancer in patients with initially elevated CEA level.