KẾT QUẢ ĐIỀU TRỊ THOÁI HÓA KHỚP GỐI NGUYÊN PHÁT BẰNG LIỆU PHÁP TIÊM NỘI KHỚP ACID HYALURONIC KẾT HỢP SORBITOL

Abstract

Objectives: Evaluate the results and the safe of intra-articular injection by hyaluronic acid combined with sorbitolto treat primary knee osteoarthritis. Subjects and methods: Prospective, interventional, vertical following-up study with a control group, 101 patients with 151 osteoarthritis knees in grade II, III according to Kellgren and Lawrence, divided into two groups: the intervention group was intra-articular injected a single Synolis VA 80/160mg into knee osteothritis,the control group was treated with oral medicine Mobic, Viatril S. Result: VAS pain score, WOMAC index, and knee range of motion of intervention group have significantly improved starting from the 4-week and continuing until the 12-week, statistically better than the control group (p<0,01). After 12 weeks, VAS score decreased from 5,28 to 1,24, The proportion of moderate and severe pain decreased from 100% to 6,8%, 39,2% no pain. The total WOMAC score reduced from 36,46 to12,27 (p<0,01). The amplitude of knee flexion increased by 19,46 ±11,84, (p<0,01). The rate of satisfaction and very satisfaction was 92,3% (p<0,01). There were no serious side effects,28,4% knee tension after injection, 12,2% painafter injection12-24 hours, 4,1% effusions. Conclusion: Intra-articular injection therapy of hyaluronic acid combined with sorbitol has a fast pain-relieving effect and improves motor function better than the control group and have quite safety.