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CHARACTERISTICS OF LANGERHANS CELL MARKERS IN PSORIATIC SKIN LESIONS TREATED WITH NARROWBAND UVB USING MINIMAL ERYTHEMA DOSE-BASED DOSAGE
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Abstract
Objective: To investigate markers CD1a and Langerin of Langerhans cells in the skin lesion of psoriasis patients treated with narrow-band UVB (NBUVB) therapy with the dose based on minimum erythema dose. Subject and research methods: Prospective descriptive study on 62 patients with moderate to severe psoriasis vulgaris receieved NBUVB regimen at the National Hospital of Dermatology and Venereology from 01/2017 to 06/2019. Immunohistochemistry was utilized to detect CD1a and Langerin markers on patients’ biopsy, in two timepoints (prior to treatment and achievement of PASI75). Result: The index of marker CD1a and Langerin at baseline had a strong correlation, 65,85±32,65 and 55,02±29,5, respectively. At the time of PASI75 achievement, these two indices showed improvement, particularly the CD1a index difference which was statistically significant. Conclusion: NBUVB therapy exerts clinical and histopathological improvement, and CD1a could be considered a marker to identify this effect.
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Keywords
psoriasis, Langerhans cell, marker CD1a, marker Langerin, narrow-band UVB
References
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