COMORBIDITIES AND GERIATRIC SYNDROMES IN OLDER PATIENTS WITH PARKINSON’S DISEASE

Lực Trần Viết, Tâm Nguyễn Ngọc, Hương Nguyễn Thị Thu

Main Article Content

Abstract

Objective: To assess some comorbidities and common geriatric syndromes in older patients with Parkinson's disease. Subjects and methods: A cross-sectional descriptive study on 190 Parkinson's patients ≥ 60 years old examined and treated at the National Geriatric Hospital. Comorbidities were assessed based on medical records. Some geriatric syndromes were assessed: polypharmacy, nutritional status, cognitive function, depression, risk of falling, sleep disorders, activities daily living. Results: The most common comorbidities were hypertension (40.5%), osteoarthritis (21.6%), diabetes (12.6%), chronic cardiovascular disease (12.6%), osteoporosis (7.4%). The average number of comorbidities was 1.9 ± 1.5 (diseases). 87.4% of patients had sleep disorders and 74.2% of participants had polypharmacy. The prevalence of malnutrition and risk of malnutrition were 7.4% and 41.1%, respectively. The prevalence of cognitive impairment was 32.1%. Signs of mild depression were present in 47.9%, while moderate to severe depression was detected in 16.3%. The prevalence of patients with high risk of falling was 78.9%. The prevalence of ADL and IADL impairment was 51.1% and 61.1%, respectively. Conclusion: This study showed a high prevalence of comorbidities such as hypertension, osteoarthritis, diabetes and geriatric syndromes such as sleep disorders, high risk of falling, polypharmacy, depression, and impaired activities daily living.

Article Details

References

1. Tysnes OB, Storstein A. Epidemiology of Parkinson's disease. J Neural Transm (Vienna). 2017;124(8):901-905. doi:10.1007/s00702-017-1686-y
2. Soh SE, McGinley JL, Watts JJ, et al. Determinants of health-related quality of life in people with Parkinson’s disease: a path analysis. Qual Life Res. 2013;22(7):1543-1553. doi:10.1007/s11136-012-0289-1
3. Lee NY, Lee DK, Song HS. Effect of virtual reality dance exercise on the balance, activities of daily living, and depressive disorder status of Parkinson’s disease patients. J Phys Ther Sci. 2015;27(1):145-147. doi:10.1589/jpts.27.145
4. Tolosa E, Ebersbach G, Ferreira JJ, et al. The Parkinson’s Real-World Impact Assessment (PRISM) Study: A European Survey of the Burden of Parkinson’s Disease in Patients and their Carers. J Parkinsons Dis. 2021;11(3):1309-1323. doi:10.3233/JPD-212611
5. Kollár B, Blaho A, Valovičová K, et al. Impairment of endothelial function in Parkinson’s disease. BMC Res Notes. 2022;15(1):284. doi:10.1186/s13104-022-06176-z
6. Abraham A, Bay AA, Ni L, et al. Gender differences in motor and non-motor symptoms in individuals with mild-moderate Parkinson's disease. PLoS One. 2023;18(1):e0272952. Published 2023 Jan 11. doi:10.1371/ journal. pone.0272952
7. Frahm N, Hecker M, Zettl UK. Polypharmacy in Chronic Neurological Diseases: Multiple Sclerosis, Dementia and Parkinson's Disease. Curr Pharm Des. 2021;27(38):4008-4016. doi:10.2174/ 1381612827666210728102832
8. Zadikoff C, Fox SH, Tang-Wai DF, et al. A comparison of the mini mental state exam to the Montreal cognitive assessment in identifying cognitive deficits in Parkinson’s disease. Mov Disord. 2008;23(2):297-299. doi:10.1002/mds. 21837
9. Gruber MT, Witte OW, Grosskreutz J, Prell T. Association between malnutrition, clinical parameters and health-related quality of life in elderly hospitalized patients with Parkinson’s disease: A cross-sectional study. PLoS One. 2020;15(5):e0232764. doi:10.1371/journal.pone.0232764
10. Gomes da Costa LV, Trippo KV, Duarte GP, Cruz AO, Filho JO, Ferraz DD. Depressive symptoms in elderly patients with Parkinson’s disease: frequency and associated factors. International Journal of Therapy and Rehabilitation. 2021;28(9):1-9. doi:10.12968/ijtr. 2019.0138