CLINICOPATHOLOGIC ANALYSIS OF STABLE VITILIGO

Tâm Hoàng Văn, Sơn Nguyễn Hồng, Hiền Đỗ Thị Thu, Yến Lê Thị Hải, Hiền Lê Thanh, Doanh Lê Hữu

Main Article Content

Abstract

Objectives: To describe the clinical, histopathological, and immunohistochemical characteristics of stable vitiligo at the National Hospital of Dermatology and Venereology. Subjects and methods: A cross-sectional, prospective study of 65 patients with stable vitiligo (including 5 cases with histopathological and immunohistochemical results) conducted from December 2020 to December 2023. Results: Segmental vitiligo accounted for 83.08% of cases, with lesions mainly located on the face, accounting for 92.31%. Time of disease stability was 6.61 ± 6.66 years. 100% of patients had opaque white lesions with demarcated margin. None of the patients had trichrome vitiligo, confetti-like pattern or Kobner sign. Of the 5 patients with histopathological results, only 1 patient had the image of dermal melanophages. 1 patient had positive result for HMB-45 (3 cells at the field of view at 40x magnification). The average number of S-100 positive cells was 17.6 ± 4.62 cells. Conclusion: There is a close correlation between clinical signs and histopathological characteristics of stable vitiligo. There is no similarity between our study and other authors in the world when using HMB-45 and S-100 to evaluate the activity level of vitiligo.

Article Details

References

1. Zhou M ni, Zhang Z qing, Wu J long, et al. Dermal mesenchymal stem cells (DMSCs) inhibit skin-homing CD8+ T cell activity, a determining factor of vitiligo patients’ autologous melanocytes transplantation efficiency. PLoS One. 2013;8(4):e60254.
2. Dev A, Vinay K, Kumaran MS, et al. Electrofulguration‐assisted dermabrasion is comparable to manual dermabrasion in patients undergoing autologous non‐cultured epidermal cell suspension for treatment of stable vitiligo: A randomized controlled trial. J of Cosmetic Dermatology. 2022;21(4):1574-1581.
3. Thakur V, Kumar S, Kumaran MS et al. Efficacy of Transplantation of Combination of Noncultured Dermal and Epidermal Cell Suspension vs Epidermal Cell Suspension Alone in Vitiligo: A Randomized Clinical Trial. JAMA Dermatol. 2019;155(2):204-210.
4. Taneja N, Sreenivas V, Sahni K et al. Disease Stability in Segmental and Non-Segmental Vitiligo. Indian Dermatol Online J. 2022;13(1):60-63.
5. Rao A, Gupta S, Dinda AK, et al. Study of clinical, biochemical and immunological factors determining stability of disease in patients with generalized vitiligo undergoing melanocyte transplantation. Br J Dermatol. 2012;166(6):1230-1236.
6. Yadav AK, Singh P, Khunger N. Clinicopathologic Analysis of Stable and Unstable Vitiligo: A Study of 66 Cases. Am J Dermatopathol. 2016;38(8):608-613.
7. Kaur G, Punia R, Kundu R et al. Evaluation of active and stable stages of vitiligo using S-100 and human melanoma black-45 immunostains. Indian J Dermatopathol Diagn Dermatol. 2020;7(1):2.
8. Hoai Thu Thi Le. Hiệu quả điều trị bạch biến thể khu trú bằng bôi tacrolimus và chiếu UVB dải hẹp. Luận văn bác sĩ nội trú (2018).