KHẢO SÁT NỒNG ĐỘ LDL-C NHỎ ĐẬM ĐẶC Ở BỆNH NHÂN HỘI CHỨNG MẠCH VÀNH CẤP

Abstract

Background: Acute coronary syndrome (ACS) remains the leading cause of cardiovascular mortality worldwide. Small dense LDL-C (sdLDL-C) is considered an independent risk factor for cardiovascular diseases. In Vietnam, there is limited research on sdLDL-C levels in patients with ACS. Objective: To investigate sdLDL-C levels in patients with ACS. Subjects and Methods: This is a cross-sectional descriptive study analyzing sdLDL-C levels in hospitalized patients diagnosed with ACS. Results: Among the 75 patients included in the study, the mean age was 61.7 ± 11.3 years, and 70.7% were male. The average sdLDL-C level in patients with ACS was 47.0 ± 21.0 mg/dL. Patients with non-ST-segment elevation myocardial infarction (NSTEMI) had the highest sdLDL-C levels at 51.4 ± 22.3 mg/dL, followed by those with unstable angina (UA) and ST-segment elevation myocardial infarction (STEMI), with sdLDL-C levels of 47.1 ± 19.5 mg/dL and 43.8 ± 20.2 mg/dL, respectively. These differences were not statistically significant (p = 0.36). Based on the extent of coronary artery disease, patients with two-vessel and left main disease had the highest sdLDL-C levels at 53.7 ± 24.4 mg/dL, followed by those with three-vessel disease (45.3 ± 17.8 mg/dL) and single-vessel disease (41.6 ± 20.2 mg/dL). However, these differences were also not statistically significant (p = 0.18). Conclusion: The study demonstrated that the mean sdLDL-C level in patients with ACS was 47.0 ± 21.0 mg/dL. There were no statistically significant differences in sdLDL-C levels among different clinical presentations of ACS or based on the number of coronary vessels involved.