ĐẶC ĐIỂM SIÊU CẤU TRÚC SẸO LỒI: SO SÁNH VÙNG TRUNG TÂM VÀ NGOẠI VI Ở NGƯỜI VIỆT NAM

Abstract

Objective: To evaluate ultrastructural characteristics of keloid scars in Vietnamese people and compare differences between central and peripheral regions. Subjects and methods: Study on 12 keloid samples of human skin tissue were taken from 06 patients that diagnosed with keloid based on JSS 2015 standards and treated with keloid surgery at Viet Nam National Institute Of Burns from February to October 2023. Samples were analyzed using JEOL JEM 1400 transmission electron microscope following ISO 9001:2015 protocol. Results: Vietnamese keloid scars maintain basic skin structure but show characteristic changes: epidermis: irregular cell arrangement, shorter desmosomes (233±7.2nm in center vs 286±6.5nm in periphery, p<0.05); basement membrane: reduced hemidesmosome density, irregular dermal papillae; dermis: increased fibroblasts and collagen with abnormal structure. These changes are more prominent in the central region. Conclusion: Keloid scars show characteristic ultrastructural changes, particularly in the central region. These findings contribute to understanding pathogenesis and treatment direction for keloids in Vietnamese people.