DẤU ẤN HBcrAg HUYẾT THANH TRONG DIỄN BIẾN TỰ NHIÊN Ở BỆNH NHÂN VIÊM GAN VI RÚT B MẠN TẠI BỆNH VIỆN BẠCH MAI

Abstract

Objectives: analyzing serum HBcrAg levels and correlation of HBcrAg with markers of hepatitis B virus in the natural of chronic hepatitis B. Methods: Cross-sectional descriptive prospective with analysis study of 127 treatment-naive chronic hepatitis B patients monitored at the Tropical Diseases Center of Bach Mai hospital. Results: HBcrAg levels in the groups of Hepatitis B e antigen (HBeAg)-positive chronic infection (EPCI), HBeAg-positive chronic hepatitis (EPCH), HBeAg-negative chronic infection (ENCI), HBeAg-negative chronic hepatitis (ENCH), Hepatitis B s antigen (HBsAg) clearance (SC) were 6.84±0.45 logU/ml; 6.7±0.59 logU/ml; 3.15±0.86 logU/ml; 4.75±1.57 logU/ml; 2.43±0.44 logU/ml, respectively. The overall correlation of HBcrAg with HBV-DNA was strong in this study (r=0.785; p=0.000), the strongest in the EPCI group (r=0.988). The correlation of HBcrAg with HBsAg was moderate (r=0.653; p=0.00). Correlation of HBcrAg with AST, ALT in the ENCH group were r=0.527, p=0.001 and r=0.335, p=0.049, respectively. In addition, HBcrAg was detectable up to 75% in the SC group. Conclusion: Serum HBcrAg levels are distributed differently groups in the natural of chronic hepatitis B. The correlation HBcrAg with HBV-DNA was strong in all groups, HBcrAg may as valuable marker for virus replication.