CLINICAL, PARACLINICAL MANIFESTATIONS AND THE ASSOCIATION WITH FATIGUE IN DENGUE FEVER PATIENTS TREATED AT HANOI MEDICAL UNIVERSITY HOSPITAL

Ngân Tạ Thị Diệu, Xuân Hoàng Thị

Main Article Content

Abstract

Objective: To describe clinical and paraclinical manifestations and the association with fatigue in dengue fever patients treated at Hanoi Medical University Hospital. Method: Descriptive study, using CFQ-11 score (Chalder Fatigue scale) to evaluate the real fatigue status of dengue fever patients. Results: Of 102 patients, 74.5% had warning signs and 25.5% had no warning signs. The most common clinical manifestations of dengue fever are fever, headache, body aches. Of them, 35.3% had itching and 42.2% had rashes. There were 74.5% of patients with platelets below 50G/l and 55.9% of patients had Hct > 50% at admission. Platelet values ​​were lowest at day 5 after symptom onset (median 48 G/L). There were 56 patients (54.9%) with real fatigue based on the CFQ-11 scale. The highest rate of fatigue was on days 3, 4 and 5 after fever appeared, 17.9%; 30.4% and 26.8% respectively. There was no association between fatigue and the severity of dengue fever and the level of platelet changes at discharge.

Article Details

References

1. Bhatt S, Gething PW, Brady OJ et al. The global distribution and burden of dengue. Nature. 2013;496 (7446):504–7.
2. Castaneda-Orjuela C, Díaz H, Alvis-Guzman N, et al., Burden of disease and economic impact of dengue and severe dengue in Colombia, 2011. Value in health regional issues, 2012; 1(2): p. 123-128.
3. M G Swain. Fatigue in chronic disease. Clinical science, 2000. 99(1): p. 1-8.
4. Halsey ES, Williams M, Laguna-Torres VA et al. Occurrence and correlates of symptom persistence following acute dengue fever in Peru. Am J Trop Med Hyg. 2014;90(3):449–56.
5. García G, González N, Pérez AB et al. Long-term persistence of clinical symptoms in dengue-infected persons and its association with immunological disorders. Int J Infect Dis. 2011;15(1):e38–43.
6. Nguyễn Văn Tại, Đặc điểm lâm sàng và kết quả điều trị bệnh sốt xuất huyết Dengue tại bệnh viện Đa khoa Kiên Giang năm 2021-2022. Tạp chí Y học Việt Nam.2022; 519 (2), tháng 10/2022: 60-64.
7. Bộ Y tế, Hướng dẫn chẩn đoán và điều trị sốt xuất huyết dengue 2011. Quyết định 458/QĐ-BYT ngày 16 tháng 2 năm 2011.
8. Craig Jackson. The Chalder Fatigue scale (CFQ 11). Occupational Medicine. 2015; 65:86. goodmedicine.org.uk. Chalder Fatigue Scale. http://www.goodmedicine.org.uk/files/assessment.chalder fatigue scale.pdf. Access 19 September 2022.
9. Cella M, Chalder T. Measuring fatigue in clinical and community settings. J Psychosom Res. 2010 Jul;69(1):17-22..