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SOME FACTORS ASSOCIATED WITH FRAILTY SYNDROME IN PATIENTS WITH PARKINSON'S DISEASE
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Abstract
Objective: to study some factors associated with frailty syndrome in Parkinson's patients. Subjects and methods: a cross-sectional descriptive study on 145 Parkinson's patients at the National Geriatric Hospital. The study subjects were interviewed according to a unified medical record, frailty was diagnosed according to Fried's criteria, including five criteria. Results: 34.5% of Parkinson's patients had frailty; 43.4% of patients had pre-frail. The rate of frailty was statistically significantly higher in the group of Parkinson's patients with older age, female, lower education level, patients without a partner (single or divorced or widowed) and higher stage of Parkinson's disease according to Hoehn and Yarh (p < 0.05). Charlson comorbidity index, duration of Parkinson's disease, and mean L-dopa dose were significantly higher in patients with frailty/pre-frail than in those without frailty. Multivariable logistic regression analysis showed that older age (OR=1.094), female (OR=4.419), duration of Parkinson’s disease (OR=1.177), Charlson comorbidity index (OR=2.266), and severity of Parkinson’s disease according to Hoehn and Yarh stage (OR=4.923) were independently associated with increased risk of frailty in patients with Parkinson’s disease. Conclusion: Age, female, duration of Parkinson’s disease, Charlson comorbidity index, and stage of Parkinson’s disease were independently associated with increased risk of frailty in patients with Parkinson’s disease.
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Keywords
Parkinson's disease, frailty syndrome, associated factors
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