KHẢO SÁT ẢNH HƯỞNG CỦA HUYẾT TƯƠNG ĐỤC ĐẾN KẾT QUẢ MỘT SỐ XÉT NGHIỆM HÓA SINH LÂM SÀNG THƯỜNG QUY

Abstract

Lipemic specimens are common in clinical chemistry and may produce significant interferences in the analytical results of different routine clinical biochemical tests. Objectives: Evaluate the influence of different triglyceride concentrations in human plasma on 12 parameters. Methods: The leftover plasma samples obtained daily in the laboratory were spiked with the different concentrations of Lipovenoes® 10% PLR, being determined a variety of biochemical tests before and after treatment. Results and conclusions: Lipemia interferes the clinical biochemical parameters. The interference increases with hypertriglycidemia levels but does not exceed the total acceptable errors for amylase, lipase, glucose, urea, creatinine, albumin, protein and potassium assays at all analyte concentrations, except for glucose at very low concentrations (< 2.2 mmol/L). The interference bias is greater than the total acceptable errors for ALT and AST testing at moderate lipemic concentration, and for sodium and chloride at severe lipemic concentration.