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Date Published: 16/12/2021
Abstract Views: 413
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DOI: https://doi.org/10.51298/vmj.v507i1.1370
Issue
Vol. 507 No. 1 (2021)
Section
Các bài báo
How to Cite
Thị Thu Hương, T. ., & Văn Liệu, N. . (2021). THE STUDY SOME CLINICAL CHARACTERISTICS AND MUTATION IN EARLY-ONSET PARKINSON PATIENTS. Vietnam Medical Journal, 507(1). https://doi.org/10.51298/vmj.v507i1.1370

THE STUDY SOME CLINICAL CHARACTERISTICS AND MUTATION IN EARLY-ONSET PARKINSON PATIENTS

Tô Thị Thu Hương1,, Nguyễn Văn Liệu1
1 Hanoi Medical University

Main Article Content

Abstract

Background: Studies about Parkinson have recently become a key topic among neurodegenerative status research. The disease was ranked at the second highest prevalence accounting for 1.6% of all neurological diseases In Parkinson's disease, an autosomal recessive gene mutation can increase a young person's risk of Parkinson's, even if only one copy of the mutated gene is inherited. Objectives: Describe some clinical features of patients with early-onset Parkinson's disease and describe some mutations in patients with early-onset Parkinson's disease. Methods: This is a cross-sectional study conducted among 30 Parkinson patients who were initially diagnosed with primary Parkinson, based on criteria for Parkinson diagnosis of the Brain bank of the Parkinson Disease Society in the United Kingdom, at the age of less than 50 years old in the National Geriatric hospital, Bach Mai hospital. Results: The mean age of onset was 41 with a male:female ratio of 1.9. The symptom of tremor at rest was the most common with the rate of 93.8%. And the most common gene mutation is GBA

Article Details

Keywords

Parkinson, mutation, early-onset parkinsonism

References

1. Gennaro Pagano, MD Nicola Ferrara, MD David J. Brooks, MD, DSc Nicola Pavese, MD, PhD. (2016) Age at onset and Parkinson disease phenotype, Neurology 86 April 12, 2016
2. Roy N. Alcalay, MD, MSc; Elise Caccappolo, PhD và cộng sự. Frequency of Known Mutations in Early-Onset Parkinson Disease. Arch Neurol. 2010; 67(9):1116-1122
3. Suganya Selvaraj, Shanmughavel Piramanayagam. Impact of gene mutation in the development of Parkinson’s disease. Genes and diseases (2019) 6, 120-128
4. Deng H, Wu Y, Jankovic J. The EIF4G1 gene and Parkinson’s disease. Acta Neurol Scand 2015: 132: 73–78 DOI: 10.1111/ane.12397, 73-78
5. Baba, Y., et al., Gender and the Parkinson’s disease phenotype. Journal of neurology, 2005. 252(10): p. 1201-1205.
6. Abbott, R.D., et al., Frequency of bowel movements and the future risk of Parkinson’s disease. Neurology, 2001. 57(3): p. 456-462.
7. Iranzo, A., et al., Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. The Lancet Neurology, 2006. 5(7): p. 572-577.
8. Giovannini, P., et al., Early‐onset Parkinson's disease. Movement disorders: official journal of the Movement Disorder Society, 1991. 6(1): p. 36-42.
9. Orozco, J.L., et al., Parkinson’s disease prevalence, age distribution and staging in Colombia. Neurology International, 2020. 12(1): p. 9-14.