CLINICAL FEATURES AND PREDICTORS OF ALCOHOL WITHDRAWAL STATUS AMONG IN-PATIENTS

Bùi Nguyễn Hồng Bảo Ngọc1,, Vũ Thy Cầm1, Nguyễn Kim Việt2
1 National Mental Health Institute, Bach Mai Hospital
2 Hanoi Medical University

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Abstract

Alcohol withdrawal status haslife-threatening compliacted such as delirium, seizure, and delirium with seizure. In Viet nam, studies on predictorsof alcohol withdrawal are limited. Research objectives: To describe the clinical features of alcohol withdrawal andanalyze predictorsof alcohol withdrawal among in-patients at Bach Mai Hospital. Subjects and research methods: cross-sectional study of 71 inpatients are diagnosed alcohol withdrawal status according to ICD 10 at Bach Mai Hospital from 08/2020 to 06/2021. Results: 100% males; symtom tremors (98,6%); sweating (97,2%); insomnia (98,6%); hypertension and tarchycardia (70,4%); history of delirium increase risk of delirium tremors (DT) are significance with p<0,001; hypokalemia increase risk of DT (OR:0,4; CI95% 0,1-0,9; p=0,04); MMSE under 24 points increase risk of DT (OR: 3,2; CI95% 1,2-8,4;p=0,02); Ciwa-Ar severe increase risk of DT (OR: 9,6; CI95% 1,95-46,8;p=0,002); history of seizure alcohol increase risk of seizure (OR:13,8; CI95%1,3-143,8; p=0,03); hypokalemia increase risk of seizure (OR: 0,2; CI95% 0,1-0,7;p=0,008). Conclusion: the main symtom of alcohol withdrawal is somatic symtom, variety and risk of serious complicated such as DT and seizure. Predictos of DT and seizure are useful in clinical practice.

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References

1. WHO (2014). Global status report on alcohol and health, 2014, Geneva.
2. Nông Thế Đoàn (2018), Đánh giá hiệu quả lâm sàng phác đồ điều trị phối hợp Diazepam và Phenobarbital trong điều trị hội chứng cai rượu, Luận văn thạc sĩ y học, Trường Đại học y Hà Nội.
3. Hoàng Văn Trọng (2004). Đặc điểm các hình thái lâm sàng loạn thần do rượu tại viện Sức khỏe Tâm thần, Luận văn Thạc sĩ y học, Trường Đại học y Hà Nội.
4. Phạm Thế Văn (2019), “Nghiên cứu đặc điểm lâm sàng và tiến triển của hội chứng cai rượu ở bệnh nhân điều trị nội trú tại Viện sức khỏe tâm thần”, Luận văn thạc sĩ y học, Trường Đại học y Hà Nội.
5. Rafael Monte et al (2009), “ Risk factors for delirium tremens in patients with alcohol withdrawal syndrome in a hospital setting”, abstracts from 8th congress of European Federation of internal medicine/ European journal of internal medicine 20S, S1 – S283.
6. Eyer Florian, et al (2011). Risk assessment of moderate to severe alcohol withdrawal – predictors for seizure and delirium tremens in the course of withdrawal. Alcohol and Alcoholism, vol. 46, No. 4, pp. 427 - 433
7. Sukanto Sarkar et al (2017), risk factor for the development of delirium in alcohol dependence syndrome: clinical and neurobiological implication, Indian journal of psychiatry, vol 59, issue 3, 300-305.
8. Berggren U, Fahlke C, Berglund K.J et al. (2009). Thrombocytopenia in Early Alcohol Withdrawal is Associated with Development of Delirium Tremens or Seizures. Alcohol and Alcoholism, 44(4), 382–386.