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DESCRIBE THE CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF OCULAR SURFACE SQUAMOUS NEOPLASIA
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Abstract
Aim: To describe the characteristics of ocular surface squamous neoplasia (OSSN) and the correlation between clinical and pathological features. Design: A retrospective cross-sectional study. Materials and methods: We analysed 180 cases of OSSN diagnosed at Ho Chi Minh Eye Hospital over a five- year period, from January 2018 to December 2022. Results: One hundred eighty patients comprising 115 (63,9%) males with a mean age of 52,5 ± 14,9 were studied. Outdoor workers accounted for 55%. The right eye was affected in 97 (54,4%) patients with no bilateral tumors. In most cases (66.11%), the tumors were located at the limbus. Histopathological examination revealed conjunctival intraepithelial neoplasia (CIN) grade I in 15 (8,3%); grade II in 123 (68,3%); grade III in 12 (6,7%), and invasive carcinoma in 30 (16,7%) cases. The mean tumor diameter was 5,2 ± 1,9 mm. Of 180 cases 91 (51,7%) were papilliform, 66 (36,6%) were gelatinous mass lesions, and 21 (11,7%) were leukoplakia lesions. The risk factor of severity of disease included: older age group, clinical appearance, tumor diameter, limbal involvement, neovascularization. The group > 60 years old was associated with 6.1 times higher-grade OSSN than the group 18 – 40 years old. Leukoplakia had 3.8 times higher risk. Limbal involvement was associated with 3 times higher grade OSSN. Tumor diameter from 5 – 10 mm had a 3 times higher risk than the group of tumor <5 mm, tumors >10 mm had a 6,7 times higher risk than the group of tumor < 5mm. Vascular OSSN had a 4 times higher tendency toward severe and invasive lesions. Papilliform appearance and tumor size were risk factors that influenced tumor recurrence. Papilliform appearance had a 6,8 times higher risk of recurrence, tumor >5mm had a 3,1 times higher recurrence rates. Conclusion: Clinical characteristics can predict the risk of disease severity and recurrence prognosis in patients with ocular surface squamous neoplasia.
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Keywords
Ocular surface squamous neoplasia, Squamous cell carcinoma
References
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