MỐI TƯƠNG QUAN GIỮA FENO VÀ MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG NGƯỜI BỆNH HEN PHẾ QUẢN ĐIỀU TRỊ TẠI BỆNH VIỆN E

Abstract

Introduction: Measurement of exhaled nitric oxide (FeNO) is a biomarker that not only plays an indirect role in assessing the level of airway inflammation but also has significance in monitoring and treating bronchial asthma. However, there have not been many studies in Vietnam evaluating the relationship between FeNO and clinical and paraclinical characteristics of bronchial asthma. Methods: The study was conducted on 30 bronchial asthma patients over 12 years old who were first diagnosed with bronchial asthma according to GINA guidelines in 2022 or had been diagnosed with bronchial asthma but had not used controlled therapy at least 03 months before at E Hospital. Clinical signs, respiratory function measurements, FeNO, total IgE, and peripheral blood eosinophils were recorded. Results: The mean age of the study group was 35.0 ± 19.14 years with mild, moderate and severe levels of 26.7%, 33.3% and 40%, respectively. The mean FeNO of the study group was 55.0 ± 52.83 ppb. FeNO concentration was correlated with small airway obstruction FEF25-75 but not with FEV1. In addition, increased FeNO was associated with total IgE concentration in serum. Conclusion: FeNO increased in asthmatic patients who were first diagnosed with asthma or were not using controller medications. FeNO was associated with small airway obstruction, total IgE but not with FEV1 or severity of asthma attacks.