TÌNH TRẠNG ĐỒNG NHIỄM VIRUS HERPES SIMPLEX VÀ MYCOPLASMA PNEUMONIAE Ở CÁC BỆNH NHÂN HỒNG BAN ĐA DẠNG

Abstract

Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous syndrome. The two most common etiologies are herpes simplex virus (HSV1,2) and Mycoplasma pneumoniae (M. pneumoniae). Identifying the etiology is a top priority in the management and treatment of EM. This cross-sectional descriptive study was conducted to determine the seropositivity rate of HSV1,2 in EM patients who tested positive for M. pneumoniae. The results showed that the HSV1,2 IgM positivity rate in patients with M. pneumoniae IgM positivity was 42.9%, whereas in the M. pneumoniae IgM-negative group, it was 15%; this difference was not statistically significant. In the group with a history of HSV1,2 exposure, the HSV1,2 IgM positivity rate in patients with M. pneumoniae IgM positivity and negativity was 25% and 15.4%, respectively. In the group without a history of HSV1,2 exposure, the HSV1,2 IgM positivity rate in M. pneumoniae IgM-positive and negative patients was 66.7% and 0%, respectively. Neither result was statistically significant. The hospitalization rate among EM patients with M. pneumoniae IgM positivity was 100%, significantly higher than in the HSV1,2 and M. pneumoniae IgM-negative group (p < 0.05). The mean age of the HSV1,2 and M. pneumoniae IgM-positive group was 14.17 ± 13.57, significantly lower than that of the HSV1,2 and M. pneumoniae IgM-negative group (p < 0.01). The mean age of the HSV1,2 IgM-positive-only group and the M. pneumoniae IgM-positive-only group was 23 ± 10.65 and 23.88 ± 13.98, respectively. There is a tendency for co-infection with HSV1,2 and M. pneumoniae, especially in young patients.