MỘT SỐ ĐẶC ĐIỂM CẬN LÂM SÀNG Ở CÁC TRẺ EM BỊ SẨN NGỨA (PRURIGO NODULARIS)

Abstract

Prurigo nodularis is a common dermatological condition in children, characterized by the presence of small nodules on the skin, accompanied by itching, scratches, and post-inflammatory hyperpigmentation. This cross-sectional descriptive study was conducted to describe certain paraclinical characteristics and serum IgE levels in pediatric patients with prurigo nodularis and to determine the relationship between serum IgE levels and clinical and paraclinical features. It was conducted on 94 children diagnosed with prurigo nodularis from August 2023 to August 2024. Total serum IgE in blood was measured using the electrochemiluminescence immunoassay (ECLIA) method on the Roche-Cobas E411 system. Results showed that 62.8% of the patients were male and 37.2% were female, with a mean age of 7.15 ± 4.21 years (ranging from 1 to 16 years). Most paraclinical indices were within normal limits. Leukocytosis was observed in 26.6% of patients, with a mean value of 8.1 ± 1.9 G/L. Normal eosinophil levels were present in 78.7% of cases, while 21.3% showed eosinophilia. Hemoglobin levels were normal in 76.6% of patients and elevated in 6.4%, with a mean value of 13.1 ± 1.9 g/dL. Normal levels of AST and ALT were observed in 85.1% and 86.2% of patients, respectively, with mean AST and ALT values of 32.9 ± 14.6 IU/L and 19.4 ± 12.3 IU/L. Elevated serum IgE levels were found in 84.0% of patients, with a mean value of 1067.726 ± 1466.142 IU/mL. There was no correlation between serum IgE levels and pruritus severity, lesion extent, and disease activity.