NGHIÊN CỨU TƯƠNG QUAN GIỮA NỒNG ĐỘ PTH MÁU VÀ CHỈ SỐ ĐỘ CỨNG ĐỘNG MẠCH Ở BỆNH NHÂN SUY THẬN MẠN LỌC MÁU CHU KỲ

Abstract

Background: Hyperparathyroidism in patients with chronic renal failure undergoing periodic hemodialysis has been shown to increase vascular stiffness in several studies. However, data on the direct correlation between serum PTH levels and arterial stiffness index in this patient population remain inconsistent. Objectives: To evaluate the correlation between serum parathyroid hormone (PTH) levels and arterial stiffness index in patients with chronic renal failure (CRF) undergoing periodic hemodialysis. Materials and methods: A cross-sectional analytical study was conducted on 91 CRF patients undergoing MHD at Vinh Long General Hospital from June 2024 to March 2025. Results: The study population had an approximately equal male-to-female ratio, with a mean age of 49.92 ± 11.29 years. Most patients had hypertension (96.7%) and a body mass index (BMI) of <23 kg/m² (80.2%). The prevalence of dyslipidemia and smoking was 8.8% and 18.7%, respectively. The mean dialysis duration was 50.71 ± 50.63 months. The median serum PTH level was 48.8 pg/mL (Q1-Q3: 30.4–94.7). The mean brachial-ankle pulse wave velocity (baPWV) was 14.54 ± 2.91 m/s. A weak positive correlation (r = 0.23) was observed between serum PTH levels and baPWV, which was statistically significant (p = 0.029). Conclusion: This preliminary study indicates a weak positive correlation between serum PTH levels and arterial stiffness index in CRF patients undergoing periodic hemodialysis.