ẢNH HƯỞNG CỦA ĐÁP ỨNG ĐIỀU TRỊ THIẾU MÁU CÓ THIẾU VITAMIN B12 VỚI NGUY CƠ TỬ VONG Ở BỆNH NHÂN SUY THẬN GIAI ĐOẠN CUỐI: NGHIÊN CỨU CAN THIỆP THEO DÕI DỌC

Abstract

IMPACT OF ANEMIA TREATMENT RESPONSE WITH VITAMIN B12 DEFICIENCY ON MORTALITY RISK IN END-STAGE RENAL DISEASE PATIENTS: A LONGITUDINAL INTERVENTIONAL STUDY
Background: Vitamin B12 supplementation improves hematological parameters such as hemoglobin levels and red blood cell count in patients with end-stage renal disease (ESRD) undergoing hemodialysis. However, the long-term effects of anemia correction through vitamin B12 supplementation on overall mortality remain controversial. Objectives: To evaluate the impact of anemia treatment response and vitamin B12 supplementation on mortality risk in ESRD patients with periodic hemodialysis and vitamin B12 deficiency. Materials and methods: A longitudinal interventional study was conducted on 32 ESKD patients with PH and vitamin B12 deficiency in Bac Lieu General Hospital from July 2023 to February 2025. Results: The male-to-female ratio was 2.2, with a mean age of 47.28 ± 15.27 years. Following anemia treatment and vitamin B12 supplementation, 100% of patients achieved target vitamin B12 levels, while 59.4% reached the target hemoglobin levels. After one year of follow-up, the mortality rate was 31.3%. Notably, patients who achieved hemoglobin response through anemia treatment and vitamin B12 supplementation had significantly higher cumulative survival rates compared to those who did not reach the target hemoglobin levels (p=0.025). Conclusion: Hemoglobin response following anemia treatment with vitamin B12 supplementation in ESRD patients with vitamin B12 deficiency undergoing PH is associated with improved overall survival.