CLINICAL CASE REPORT: PTH HYPERSECRETORY PARATHYROID TUMOR CAUSING COMPLICATIONS: SEVERE OSTEOPOROSIS, PATHOLOGICAL FRACTURES – PARAPLEGIA

Hoàng Phan Minh, Thuận Nguyễn Lê, Duy Đặng Công, Thoại Cao Đức, Thắng Lê Tất, Phượng Đỗ Thị Mỹ, Như Lục Nguyễn Quỳnh

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Abstract

Primary hyperparathyroidism (PHPT) is a common endocrine disorder that leads to excessive secretion of parathyroid hormone (PTH), hypercalcemia and secondary osteoporosis. We present a case of a patient with undiagnosed PHPT, resulting in severe osteoporosis and vertebral compression fractures following minor trauma. The patient experienced spinal cord injury and paraplegia, confining her to bed for three years. She received supportive medical treatment with cinacalcet and bisphosphonates prior to surgery. Parathyroidectomy remains the only definitive treatment, with a cure rate exceeding 95%. Postoperatively, PTH and serum calcium levels returned to normal, preventing long-term renal complications. However, the severe osteoporosis and bone degradation at multiple sites over the past three years make the prognosis for functional recovery poor. This case highlights the importance of early diagnosis of PHPT and timely intervention to prevent severe complications.

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References

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