ASSOCIATION BETWEEN RS1056836 POLYMORPHISM OF CYP1B1 GENE AND CERTAIN CLINICAL AND PARACLINICAL FEATURES IN PATIENTS WITH PRIMARY ANGLE-CLOSURE GLAUCOMA
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Abstract
Objective: To determine the association between CYP1B1 rs1056836 polymorphism and certain clinical, paraclinical features in patients with primary angle-closure glaucoma (PACG). Subjects and Methods: A clinical descriptive study was conducted on 101 PACG patients at 103 Military Hospital, Hanoi Eye Hospital branch 1 and branch 2 from January 1, 2023, to August 31, 2024. Results: There are three genotypes CC, CG and GG; The CC genotype was the most common (86.1% in the PACG group and 83.3% in the control group). No significant association was found between rs1056836 polymorphism and family history, ocular axial length, anterior chamber depth, lens thickness and history of diabetes (p > 0.05). However, the CG genotype was more prevalent in the chronic PACG group (29.2% compared to the acute PACG group 9.1%), and in the hypertension (25.7% compared to the without hypertension 7.6%), p < 0.05. There is an association between rs1056836 polymorphism and progression of anterior chamber angle closure and concomitant hypertension in patients with PACG. Conclusion: The rs1056836 polymorphism was associated with acute/chronic disease and hypertension, but no significant association was observed with family history, axial length of the eyeball, anterior chamber depth, or lens thickness and history of diabetes.
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Keywords
rs1056836, CYP1B1, primary angle-closure glaucoma
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