KẾT QUẢ BƯỚC ĐẦU CỦA PHẪU THUẬT CẮT THỰC QUẢN SAU HÓA XẠ ĐỒNG THỜI TÂN HỖ TRỢ UNG THƯ THỰC QUẢN GIAI ĐOẠN TIẾN TRIỂN TẠI CHỖ TẠI VÙNG

Abstract

Introduction: Esophageal cancer is a highly aggressive malignancy with a rising global incidence and poor prognosis. Neoadjuvant chemoradiotherapy (nCRT) in conjunction with radical esophagectomy has demonstrated superior outcomes compared to primary surgery in the treatment of locally advanced esophageal cancer. However, most existing studies have been conducted in Western populations, while data from Asian countri es, particularly Vietnam, remain limited. Aim: This study aims to evaluate the safety and viability of implementing radical esophagectomy surgery following nCRT in patients with locally advanced esophageal cancer. Methodology: A retrospective descriptive study was conducted on 46 patients diagnosed with locally advanced esophageal cancer who underwent nCRT followed by McKeown esophagectomy with lymph node dissection at the Department of Abdominal and Thoracic Surgery, Oncology Hospital, Vietnam, between December 2020 and June 2024. Result: Baseline characteristics indicated that all participants were male, with 71.8% identified as smokers and 45.6% having a history of alcohol consumption. The median interval between completion of nCRT and surgery was 65 days. The median operative duration was 320 minutes, with a median blood loss of 180 mL. Perioperative mortality was 2,2% and postoperative pulmonary complications were 30,4%. The median postoperative hospital stay was 14 days. All patients achieved R0 resection margins, with 47,8% demonstrating a pathological complete response (pCR). Conclusion: The study’s outcomes emphasize the safety and feasibility of employing McKeown esophagectomy following nCRT in Vietnamese patients, with an acceptable complication rate and favorable surgical outcomes.