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Date Published: 05/05/2025
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DOI: https://doi.org/10.51298/vmj.v549i3.13938
Issue
Vol. 549 No. 3 (2025)
Section
Các bài báo
How to Cite
Trần Thị, H., & Nguyễn Thị, V. (2025). SEROLOGICAL DIAGNOSIS OF EPSTEIN-BARR VIRUS IN PATIENTS WITH ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME, AND TOXIC EPIDERMAL NECROLYSIS. Vietnam Medical Journal, 549(3). https://doi.org/10.51298/vmj.v549i3.13938

SEROLOGICAL DIAGNOSIS OF EPSTEIN-BARR VIRUS IN PATIENTS WITH ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME, AND TOXIC EPIDERMAL NECROLYSIS

Huyền Trần Thị, Vinh Nguyễn Thị

Main Article Content

Abstract

A cross-sectional descriptive study was conducted on 54 patients with erythema multiforme (EM), 30 patients with Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), and 30 healthy individuals to determine the seropositivity rate for Epstein-Barr virus (EBV) and its association with certain clinical features. The results showed that the rates of EBV-IgM and EBV-IgG positivity were 3.33% and 100% in the SJS/TEN group, 9.26% and 98.15% in the EM group, and 3.33% and 100% in the healthy group, respectively. The differences among the groups were not statistically significant. In the EM group, patients with acral, localized lesions had a higher EBV-IgM seropositivity rate (50%) compared to those with diffuse skin lesions (4.17%), with p < 0.05. Additionally, the EBV-IgM positivity rate in patients with mucosal involvement (23.08%) was higher than in those without mucosal involvement (4.88%), but this difference was not statistically significant (p > 0.05).

Article Details

Keywords

Epstein-Barr virus, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis

References

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