NGHIÊN CỨU MỘT SỐ YẾU TỐ TIÊN LƯỢNG UNG THƯ HẮC TỐ DA TẠI BỆNH VIỆN K TỪ 2009 ĐẾN 2019

Abstract

Objective: Study on clinical,histopathological featuresand some prognostic factors of cutaneous melanoma. Subjects and methods: A retrospective and prospective  study on 207 cutaneous melanoma patients in stage II, III were treated with surgery at K hospital from 2009 to 2019. Results: The average age is 55,0 ± 0,9, which is common from 40 to 79 years, youngest patient 18 years-old and the oldest one 85 years-old, female/male 1,13. Tumors are often located in the lower limbs, superficial spreading melanoma 61,7%, thickness 2,1-4,0mm 29,8%, > 4,0mm 67,4%. Clark V 51,8%, Clark IV 34%, the vertical development stage 75,2 %, satellite  30,5%, ulcer 43,2%, invasion to blood vessel 22%. In tumors invade mesoderm, mitosis > 6/mm² 38,3%, sparse invasive lymphocytesgroup 33,3%, without invasive lymphocytes group 36,2 %. Lymph node metastasis 45,9%, stage 2, 3 is 45,9%, 54,1%. The overall 5-year survival rate is 42.4%. Prognostic factors affect the overall 5-year survival rate: tumor location, histopathological type, thickness, Clark, developmental stage, satellite, ulcer, invasion to blood vessel, invade mesoderm, invasive lymphocytes, number of lymph nodes metastasis and stage. Conclusion: Common age 40-70, female/male is 1,13, lower limbs 62,3%, superficial spreading melanoma 61,7%, >4,0mm 67,4%. Clark V 51,8%, the vertical development stage 75,2 %, satellite  30,5 %, ulceration 43,2%, invasion to blood vessel 22%, invade mesoderm, mitosis > 6/mm2 is 38,3%. Lymph node metastasis 45,9%, stage 2, 3 is 45,9%, 54,1%. The overall 5-year survival rate 42.4%. Prognostic factors: tumor location, histopathological type, thickness, Clark, developmental stage, satellite, ulcer, invasion to blood vessel, invade mesoderm, invasive lymphocytes, number of lymph nodes metastasis and stage.