ĐẶC ĐIỂM, NGUYÊN NHÂN VÀ MỘT SỐ YẾU TỐ NGUY CƠ NHIỄM KHUẨN NẶNG Ở TRẺ SƠ SINH TẠI TRUNG TÂM NHI KHOA, BỆNH VIỆN BẠCH MAI, NĂM 2023

Abstract

Objective: To explore the causes and risks factors, and to evaluate the treatment results of severely infected newborns at Pediatric center, Bach Mai Hospital. Methods: A cross-sectional study was conducted on pediatric patients under 28 days of age diagnosed with neonatal sepsis. Clinical and paraclinical symptoms of the pediatric patients were collected. Treatment methods (medication, procedural intervention) and treatment outcomes were described. Results: Serum albumin concentration can be a predictor of the severity of neonatal infection. Thrombocytopenia can be a useful factor in diagnosing and predicting the treatment outcomes of neonatal infection with negative blood culture/infection site results. The mortality rate was still high (23.4%) and is all premature infants, especially when the infant has septic shock requiring vasopressor use. The more premature the infant, the longer the duration of mechanical ventilation; the longer the duration of antibiotic use, the longer the treatment time in the ICU, and the longer the treatment time in the hospital. The rate of positive blood culture/infection site is 27%, in which the predominant is Gram (-) bacteria, especially multi-resistant Klebsiella. Conclusion: The rate of neonatal infections in premature infants was high and they had high mortality rate. There is a need for early diagnosis and effective treatment strategies for these patients.