GIÁ TRỊ CỦA TỈ SỐ LDL-C/HDL-C TRONG DỰ BÁO TẮC NGHẼN ĐỘNG MẠCH VÀNH Ở BỆNH NHÂN ĐAU THẮT NGỰC ỔN ĐỊNH

Abstract

Objective: To determine the predictive value of the LDL-C/HDL-C ratio for obstructive coronary artery disease (OCAD) in patients with stable angina (SA). Methods: A cross-sectional study was conducted on 366 SA patients (mean age 64.8 ± 9.1 years, 62.6% male). Clinical, laboratory, and coronary computed tomography angiography (CCTA) data were collected. OCAD was defined as luminal stenosis ≥ 50% in at least one major epicardial coronary artery on CCTA. Results: Patients with OCAD had a higher prevalence of male sex, smoking, hypertension, dyslipidemia, and a family history of premature coronary artery disease. They were more likely to experience typical chest pain and less likely to have atypical chest pain or dyspnea. This group also had higher levels of creatinine, uric acid, total cholesterol, triglycerides, and the LDL-C/HDL-C ratio, while HDL-C levels were lower (all p < 0.05). The area under the ROC curve of the LDL-C/HDL-C ratio in predicting OCAD was 0.627 (95% CI: 0.568-0.686, p < 0.001), with a cutoff value of >2.25, a sensitivity of 45.9%, and a specificity of 79.2%. In multivariable logistic regression analysis, the LDL-C/HDL-C ratio was an independent predictor of OCAD (odds ratio 1.60, 95% CI: 1.13-1.27, p = 0.009). Conclusion: The LDL-C/HDL-C ratio is a valuable predictor of OCAD in SA patients, contributing to improved risk assessment and treatment decision-making.